Ozempic for weight loss: Ozempic review, instructions, contraindications

Ozempic is an innovative drug that has recently gained widespread popularity as a weight loss aid. Originally developed to treat type 2 diabetes, Ozempic has unexpectedly shown itself to be an effective weight loss drug. Its ability to suppress appetite and speed up metabolism has attracted the attention of both doctors and patients suffering from overweight and obesity.

What is Ozempic

Ozempic is the trade name of a drug containing the active substance semaglutide. Chemically, semaglutide is a glucagon-like peptide-1 (GLP-1) analogue. It was approved by the US Food and Drug Administration (FDA) for the treatment of type 2 diabetes in 2017 and for weight loss in 2021. The main purpose of Ozempic is to control blood glucose levels in patients with type 2 diabetes. However, during clinical trials, a significant side effect was found – significant weight loss in patients taking this drug.

Ozempic was originally developed by Novo Nordisk for the treatment of diabetes. Its ability to lower blood sugar levels and improve insulin sensitivity made it an important tool in the fight against diabetes. However, it soon became apparent that the drug had an additional benefit – it helps patients lose weight, which is especially important for people with diabetes, who are often overweight or obese.

What is Glucan-Like Peptide-1 (GLP-1)

Glucan-like peptide-1 (GLP-1) is a hormone that plays a key role in regulating blood glucose levels and appetite. It is produced in the intestines in response to food intake and has many important effects on the body:

1. The injection stimulates the pancreas to produce insulin, which helps lower blood sugar levels.
2. Suppresses the secretion of glucagon, a hormone that increases blood glucose levels.
3. Slows down the emptying of the stomach, which promotes a longer feeling of satiety.
4. Affects the appetite centers in the brain, reducing the feeling of hunger.

In the context of Ozempic, which is a GLP-1 analogue, these effects are enhanced and prolonged. This means that the drug not only helps control blood sugar levels in diabetics, but also effectively suppresses appetite, which leads to a decrease in calorie intake and, as a result, weight loss.

When is Ozempic prescribed?

Ozempic injections are prescribed in the following cases:

1. Treatment of type 2 diabetes: This is the primary indication for prescribing the drug. Ozempic helps control blood glucose levels and improves insulin sensitivity.
2. Obesity: The drug is often prescribed to patients with a body mass index (BMI) of 30 or higher, or 27 or higher in the presence of comorbidities associated with excess weight.
3. Overweight: Ozempic injections can be prescribed to people with a BMI of 25 to 29.9, especially if traditional weight loss methods have proven ineffective.
4. Prevention of cardiovascular diseases: in patients with type 2 diabetes and a high risk of cardiovascular complications.
5. Metabolic syndrome: a complex of metabolic disorders including obesity, impaired glucose tolerance, dyslipidemia, and arterial hypertension.

It is important to note that Ozempic is not a first-line treatment for obesity and should only be prescribed under the supervision of a physician after a thorough assessment of the patient’s health status and potential risks.

Who and how Ozempic helped to lose weight

Ozempic has shown impressive results in weight loss for many patients. Here are some real success stories:

Brittany, over 100 pounds. Before and after. Brittany started her weight loss journey at 209 pounds and was able to lose 100 pounds thanks to Ozempic and a healthy lifestyle. She emphasizes that the weight loss was slow but steady, and that it was due to moderation in food and exercise.(Body Network).

u/PAR0824, 27. Before and After. u/PAR0824, a 27-year-old woman, lost 71 pounds in a year, going from 196 pounds to 125 pounds. She says the drug changed her life, but it also led to new health issues, like low blood pressure and a POTS diagnosis. (SET FOR SET).

u/MamaVasy, 39. Before and after. u/MamaVasy, a 39-year-old woman, used Ozempic in combination with calorie counting and lost 40 pounds in 5 months. She discovered that she had insulin resistance, which explained her previous difficulty losing weight. Doctors recommended that she continue taking the drug to maintain the results. (SET FOR SET).

Danielle Peyton, 33. Before and After. Danielle, a 33-year-old communications professional from Miami, lost 80 pounds in four years, starting at 209 pounds. She decided to use drugs similar to Ozempic to avoid developing diabetes, which ran in her family. The side effect was significant weight loss and improved overall health. (Marie Claire UK).

Redditor tbacks97. Before and after. Redditor tbacks97 went from 205 pounds to 136 pounds in eight months using Ozempic. She described the change as liberating, noting that she was no longer held back by the extra weight and could move freely. (Body Network).

Patient Jamison. Before and after. “I have been taking 0.5 mg of Ozempic for two months now. The nausea is constant. I vomit almost every day, which has almost caused two accidents. I have lost 30 pounds, but I feel terrible. My stomach hurts all the time, and now my back hurts. I hardly pee, even though I drink more water. Calling my doctor today to stop. The weight loss is great, but not at the cost of feeling bad every day.” (Drugs.com).

These stories demonstrate how Ozempic has helped people achieve significant weight loss and overall health improvements. However, it is important to remember that the drug must be used under the supervision of a doctor and in combination with lifestyle changes to achieve lasting results.

Typical results when using Ozempic for weight loss:

• On average, patients lose 10-15% of their initial weight in 6-12 months.
• The most noticeable weight loss occurs in the first 3-4 months of taking the drug.

Many report improvements in health indicators such as blood sugar levels and blood pressure.
By the way, we suggest you watch a video about weight loss and abdominoplasty surgery by Dmitry Azovsky, a blogger and bodybuilder, where he talks about his experience of gaining weight up to 160 kg for the sake of popularity on social networks and subsequent weight loss. He came to us at GlobalMedik in Turkey to undergo abdominoplasty after a sharp weight loss. The video shows the process of preparation for the operation, its implementation and the first results.

How Ozempic Works

Ozempic’s mechanism of action is based on its ability to mimic the action of the natural hormone GLP-1. At the cellular level, the drug works as follows:

1. Binding to receptors. Semaglutide molecules (the active substance of Ozempic) bind to GLP-1 receptors on the surface of cells in the pancreas, stomach, and brain.
2. Stimulation of insulin production. In the pancreas, Ozempic stimulates beta cells to produce insulin, which helps reduce blood glucose levels.
3. Suppression of glucagon secretion. At the same time, the drug suppresses the production of glucagon, a hormone that increases blood sugar levels.
4. Slowing down gastric emptying. Ozempic affects the muscles of the stomach, slowing its emptying. This leads to a longer feeling of satiety after eating.
5. Effect on appetite centers in the brain. The drug affects the hypothalamus, the area of ​​the brain responsible for regulating appetite, which leads to a decrease in hunger and a decrease in food intake.

Due to these mechanisms, Ozempic effectively reduces appetite and increases satiety, which, in combination with proper nutrition and physical activity, leads to sustainable weight loss.

Clinical studies have shown that Ozempic leads to weight loss of an average of 15-20% in a year and a half, and also improves liver function and reduces the risk of cardiovascular disease. (The Hub).

How to take Osempic for weight loss

Instructions for use of Ozempic for weight loss:

1. Release form. Ozempic is available as a solution for subcutaneous injections in pre-filled syringe pens.
2. Initial dosage. Treatment usually begins with a dose of 0.25 mg once a week for the first month.
3. Dose increase. After the first month, the dose is increased to 0.5 mg once a week. If necessary, after 4 weeks, the dose can be increased to 1 mg once a week.
4. Time of administration. The injection can be done at any time of the day, regardless of food intake.
5. Injection site. The drug is administered subcutaneously in the abdomen, thigh or shoulder.

Important notes:

• Do not change the dose without consulting your doctor.
• Check your blood sugar regularly, especially at the beginning of treatment.
• Combine your medication with a healthy diet and physical activity for best results.
• If you miss a dose, take the injection as soon as possible within 5 days of the missed dose. If more than 5 days have passed, skip the dose and take the next injection as usual.

Main contraindications

Before starting to take Ozempic, it is important to consider the following contraindications:

1. Type 1 diabetes mellitus. Ozempic is not intended for the treatment of type 1 diabetes.
2. Pregnancy and breastfeeding. The drug may cause harm to the fetus or newborn.
3. Pancreatitis. People with a history of pancreatitis should avoid taking Ozempic.
4. Medullary thyroid cancer. The drug is contraindicated in patients with this disease or its family history.
5. Multiple endocrine neoplasia type 2. Ozempic should not be taken by people with this syndrome.
6. Severe gastrointestinal disease. Including gastroparesis or inflammatory bowel disease.
7. Allergy to semaglutide or any component of the drug.
8. Severe renal or hepatic impairment. Special caution and dose adjustment are required.

The following groups of people should take Ozempic with caution:

• Elderly people (over 65 years) due to increased risk of side effects.
• People with cardiovascular disease.
• Patients with thyroid disease.
• People with a history of depression or suicidal thoughts.

Before starting treatment with Ozempic, you should consult with your doctor to assess your individual risks and benefits of treatment.

Doctors’ opinions

The use of Ozempic for weight loss has caused active discussions in the medical community. Many doctors acknowledge the effectiveness of the drug, but emphasize the need for a cautious approach to its prescription.

Dr. Eleanor Yusupov, RD, Lecturer at the New York Institute of Technology: “Ozempic really helps my patients control their appetite and lose weight. Although some of them experience temporary side effects such as nausea and constipation, these usually go away within a few weeks. I believe that to achieve long-term results, it is necessary to combine the drug with lifestyle changes.”

Dr. Mustafa Ozturk, Endocrinologist, Medipol University Hospital, Istanbul: “Ozempic helps many patients with obesity and type 2 diabetes. It reduces appetite and helps to reduce weight significantly. However, it is important to remember about regular check-ups and health monitoring, especially for people with retinopathy and pancreatitis.”

Associate Professor Dr. Idris Kuzu, Endocrinology and Metabolic Diseases, Istanbul Memorial Hospital: “With my patients using Ozempic, I see excellent results in weight loss and improved blood sugar control. The drug is effective, but it is important for patients to monitor their overall health and have regular check-ups.”

Professor Dr. Taner Damci, Endocrinologist, Memorial Hospital: “I prescribe Ozempic to my patients with obesity and type 2 diabetes. The drug shows good results in weight loss and improvement of general health. It is important to remember that to maintain the results, it is necessary to continue to adhere to a healthy lifestyle.”

Dr. Susan Johnson, endocrinologist, Healthline: “Ozempic can indeed help with weight loss, but it is not a miracle cure. Diet and exercise must be continued for long-term results. Some patients experience side effects such as nausea and digestive issues, which require close monitoring.”

Dr. Alyssa Lowry, MD, PhD, Penn Medicine: “While Ozempic has shown good results in weight loss, it is not for everyone. Patients with a predisposition to pancreatitis and thyroid problems may be at risk for complications. I recommend discussing this medication carefully with your doctor before starting a course.”

The general opinion of the medical community is that Ozempic is an effective weight loss tool, but its use should be carried out under strict medical supervision and taking into account the individual characteristics of each patient.

Conclusion

Ozempic is an innovative drug originally developed to treat type 2 diabetes, but has shown significant effectiveness in combating excess weight and obesity. The active substance semaglutide, an analogue of the hormone GLP-1, has a complex effect on the body, reducing appetite, slowing gastric emptying and improving blood glucose control.

Main conclusions:

1. Efficiency: Ozempic shows impressive results in weight loss, especially in patients with obesity and type 2 diabetes.
2. Mechanism of action: The drug works by mimicking the action of the natural hormone GLP-1, which leads to a decrease in appetite and improved metabolism.
3. Application: Ozempic is administered subcutaneously once a week, with a gradual increase in the dose under the supervision of a doctor.
4. Contraindications: The drug has a number of serious contraindications and is not suitable for all patients with excess weight.
5. Expert opinion: Doctors recognize the effectiveness of Ozempic, but emphasize the need for a cautious approach and individual selection of therapy.

Recommendations for use of Ozempic:

1. Always consult your doctor before starting to take the drug. Ozempic should only be prescribed by a specialist after a thorough assessment of your health.
2. Combine taking the drug with a healthy lifestyle, including proper nutrition and regular physical activity.
3. Undergo regular medical examinations and tests to monitor the effectiveness of treatment and identify possible side effects.
4. Be prepared for a long course of treatment. Ozempic is not a quick solution to the problem of excess weight.
5. Tell your doctor about any side effects or changes in your health while taking the drug.
6. Do not stop taking Ozempic on your own without consulting your doctor.

In conclusion, it is worth noting that although Ozempic offers new options in the treatment of obesity, it is not a one-size-fits-all solution. A healthy lifestyle, balanced diet and regular exercise remain key factors in achieving and maintaining a healthy weight.